Every 65 seconds, someone in America is told they have Alzheimer’s disease. Today, more than 6 million Americans are living with the disease that steals our memories and impacts our minds.
Alzheimer’s disease is being called a health crisis as worldwide care is estimated at more than $1 trillion, and it’s expected to get worse.
There is no cure, but new research reveals that how you eat and sleep could impact it, suggesting that our circadian rhythm, or internal clock, could play a role in cognitive decline.
“Eighty percent of the patients that suffer Alzheimer’s disease will manifest some in the regulation. These patients will be very sleepy during the day, but then, during the night, they will be awake,” said Paula Desplats, Professor in the Department of Neurosciences at UC San Diego School of Medicine.
Desplats’ team at UC San Diego is one of the first to study how intermittent fasting could impact our internal clocks, affect our sleep and change our brains.
“The rhythms of activities throughout the day and these rhythms are broken, that is even a biomarker or a potential predictor of developing dementia down the road,” Desplats said.
In the study, the mice’s diet was what would be equivalent to 14 hours of fasting for people. The animals exhibited better memory and regular sleep patterns.
“These animals that were fasting had really fewer senile plaques in the brain,” Desplats said.
The next step -- human clinical trials. And unlike drug-based treatments, this lifestyle change could be a simple way to prevent and slow the progression of the devastating disease.
“If we can improve, if we can change, even a little bit, this progression curve, if we can keep these patients with their families, that’s what we want to try to do,” Desplats said.
Alzheimer’s disease may not be the only disease impacted by our circadian rhythms. Other studies in mice have shown that it also may impact people with Huntington’s disease.