A recent study from Cleveland Clinic found genetics may play a bigger role than originally thought when it comes to melanoma.
According to Dr. Joshua Arbesman, a dermatologist and researcher for Cleveland Clinic, they looked at different genes in individuals with a history of melanoma.
“What we found when we screened these patients is that about 15 percent of the patients had what we call a pathogenic variant, meaning a change in a gene that increases your risk for cancer,” said Arbesman.
Arbesman said two-thirds of the genes they found that were significantly altered were not in genes previously associated with melanoma.
So, why is this important?
He said it could provide more insight into who is at risk for not just melanoma, but other cancers too.
In addition, it could expand who is eligible for genetic testing.
Currently, physicians rarely order genetic testing for individuals with a personal history of melanoma, and insurance companies often don’t cover it.
And that’s due to the previous lack of research in this area.
Arbesman also hopes it’ll lessen any guilt some cancer patients have.
“I think a lot of people that develop melanoma sometimes feel some sense of guilt over their past sun exposure, some of which was not controlled by them because it was during childhood,” he said. “And what I would say is that there’s a large portion of the risk that was not determined by anything that they did. The genetics may play a larger role. And so not feeling guilty about their previous exposure is important as well.”
Arbesman said their research is ongoing.
They plan to study more individuals with melanoma, and also see if they can identify any other genes that can put a person at risk for cancer.