Marco Wilson and Isaiah Simmons scored touchdowns on two pick-6s late in the first half and used that stunning change in momentum to lift the Arizona Cardinals over the New Orleans Saints 42-34.

Can we finally start Tony Pollard.

Ryan Tannehill ran and threw for touchdowns as the Tennessee Titans held off the New Orleans Saints 23-21 on Sunday for their NFL-best sixth straight victory.

Jameis Winston passed for touchdowns of 43 and 29 yards to Marquez Callaway, and the New Orleans Saints defeated the Jacksonville Jaguars 23-21 in a preseason game.

Let’s start with:PAYTON’S PLANOn Christmas night, Saints running back Alvin Kamara tied a 91-year-old NFL record by rushing for six touchdowns in a 52-33 wipeout of the Minnesota Vikings. “I was thinking about our best play there,” Payton explained afterward. Payton wasn’t talking about Nevers’ record six TD runs. “A lot of these players — I’d say most of these players — have no idea how good Gale Sayers was,” said Payton. “It was a great moment.”Brees said Payton mentioned Sayers’ mark before the Saints’ last touchdown drive.

Brees threw for 222 yards and four touchdowns, regaining the NFL career TD pass lead and lifting the New Orleans Saints into first place with a 38-3 rout of Brady and the Tampa Bay Buccaneers on Sunday night. The Saints intercepted Brady twice in a 34-23 season-opening win, with Janoris Jenkins returning one for a TD. “We didn't play well in any phase of the game,” Brady said. But with Tampa Bay’s offense sputtering and one of the league’s stingiest defenses unable to slow down Brees, New Orleans pressed on. Buccaneers: WR Chris Godwin (three catches, 41 yards) returned after missing one game with a broken right index finger.