A son of former Sinaloa cartel leader Joaquin “El Chapo” Guzmán has pleaded not guilty in federal court in Chicago.

The United States has sanctioned a son of Mexican drug lord Joaquin “El Chapo” Guzman, three members of the Sinaloa cartel and two Mexican-based firms, alleging they trafficked fentanyl and other drugs into the U.S. Tuesday's sanctions came the day Mexican President Andrés Manuel López Obrador talked with President Joe Biden about immigration and the fentanyl crisis.

She is the wife of Mexican drug kingpin Joaquin El Chapo Guzman and is accused of helping her husband run his multibillion-dollar cartel and plot his audacious escape from a Mexican prison in 2015. (Alexandria Adult Detention Center via AP)WASHINGTON – The wife of Mexican drug kingpin Joaquin “El Chapo” Guzman was arrested in the United States and accused of helping her husband run his multibillion-dollar cartel and plot his audacious escape from a Mexican prison in 2015. She is a dual citizen of the United States and Mexico. Her arrest is the latest twist in the bloody, multinational saga involving Guzman, the longtime head of the Sinaloa drug cartel. After Guzman was rearrested following his escape, Coronel lobbied the Mexican government to improve her husband’s prison conditions.

Emma Coronel Aispuro, the wife of Joaqun "El Chapo" Guzmn, arrives at federal court ahead of her husband's sentencing.

But if the appeal is not successful, "then this will be the last time the public will see El Chapo," Colon told CNN. "It could be potentially also the last time El Chapo could see his wife." He is limited to phone calls and visits from certain family members, including his twin 8-year-old daughters. In 2001 Guzman escaped by hiding in a laundry cart. Guzman escaped from the Mexican prison a second time, on July 11, 2015.

(CNN) - Prosecutors on Wednesday submitted a memo asking for Joaquin "El Chapo" Guzmn to receive life in prison. Prosecutors argue those counts should be dismissed because they encompass some of the same charges as count one, which is a "continuing criminal enterprise" charge. Conviction of the top charge of engaging in a continuing criminal enterprise carries a mandatory term of life in prison. Jeffrey Lichtman, an attorney for Guzmn, said his team expected the life sentence recommendation from prosecutors. Last week, prosecutors asked the judge to order Guzmn to pay a criminal forfeiture of about $12.7 billion to the US government.

(CNN) - A federal judge in New York Wednesday denied drug kingpin Joaquin "El Chapo" Guzman's bid for a new trial. The count of engaging in a continuing criminal enterprise carries a mandatory term of life in prison. Defense attorney Jeff Lichtman, in a statement, said Wednesday that the ruling further demonstrated the trial "was more of an inquisition, a show trial, than an exercise in true American justice." In March, Guzman's attorneys asked Cogan for a new trial and to recall the jurors back for an evidentiary hearing to find out if there had been misconduct. Prosecutors responded that the court's repeated instruction to jurors, their diligence during the trial, and overwhelming evidence against Guzman show that "the alleged media exposure did not prejudice the defendant."