Jaguars return specialist Jamal Agnew is inactive for Jacksonville’s game against the Denver Broncos at Wembley Stadium.

Davis Mills threw a touchdown pass to Chris Moore to help the Houston Texans beat the San Francisco 49ers 17-0 on Thursday night in the preseason finale for both teams.

The Indianapolis Cots have placed five players on the COVID-19 list as the virus continues to work its way through NFL locker rooms, even with the vast majority of players in the league vaccinated.

The Arizona Cardinals will be without Pro Bowl running back James Conner and rookie receiver Rondale Moore as they try to clinch a playoff spot on Saturday by beating the Indianapolis Colts.

Start with running back, where Giants star Saquon Barkley is believed to have torn the ACL in his right knee early in their loss at Chicago. The 49ers' Jimmy Garoppolo tried to play through a right ankle injury before Nick Mullens took over for the second half. Tevin Coleman also left San Francisco's win over the Jets with a late knee injury. Along with Lock and Sutton, the Broncos lost defensive end Dre'Mont Jones to a knee injury in their defeat at Pittsburgh. Washington guard Brandon Scherff, who left early in Arizona with a knee injury, was among the offensive linemen hurt around the NFL on Sunday.

FILE - In this Oct. 24 2019, file photo, Minnesota Vikings running back Dalvin Cook walks on the field before an NFL football game against the Washington Redskins in Minneapolis. The Vikings have centered their offense around running back Dalvin Cook and praised him at every turn, but now the bill has come due. (AP Photo/Bruce Kluckhohn, FIle)MINNEAPOLIS Dalvin Cook logged off last week from virtual team activities with the Minnesota Vikings, no longer willing to participate until he has secured a new contract. The three-year, $39 million contract Arizona gave David Johnson, who's now with Houston, might be the most realistic model. Gordon took a two-year, $8 million contract with Denver.

The return of Nick Foles was supposed to be the launching point to the second half of the season. Instead, it put a stamp on just how much work lies in front for the Jaguars to become a competitive NFL team. The Jaguars (4-6) needed to close the season out strong to have a shot to reach the playoffs. The pair of 100-yard rushers marked the first time that the Colts had done that in franchise history. Brissett added a 5-yayrd rushing touchdown A 48-yard run by Williams on the following drive set up a Nyheim Hines 7-yard touchdown run and the blowout was on.