U.S. authorities say arrests for illegally crossing the border from Mexico fell 7% in September to a more than four-year low.

Fernando Tatis Jr.‘s towering two-run home run highlighted a six-run second inning, and the San Diego Padres held on to beat Shohei Ohtani and the rival Los Angeles Dodgers 6-5 to take a 2-1 lead in a tense NL Division Series.

The Braves’ best pitcher, NL Cy Young Award favorite Chris Sale, was back home in Atlanta with a back injury.

A San Diego doctor charged in connection with Matthew Perry's fatal overdose has pleaded guilty to conspiring to distribute the surgical anesthetic ketamine.

Fernando Tatis Jr. hit a towering two-run homer on his first playoff swing in four years and Michael King struck out 12 in his first postseason start as the San Diego Padres beat rookie AJ Smith-Shawver and the Atlanta Braves 4-0 in Game 1 of their NL Wild Card Series.

The San Diego Padres clinched a playoff spot Tuesday night when they stunned the Los Angeles Dodgers with a game-ending triple play to preserve a 4-2 victory over the NL West leaders.

The Chicago White Sox had a 2-1 lead going into the bottom of the eighth inning, and then history struck.

The Chicago White Sox tied the post-1900 record of 120 losses by the 1962 expansion New York Mets when the San Diego Padres won 4-2 by rallying for three runs in the eighth inning, highlighted by Fernando Tatis Jr.’s towering home run.

California now has some of the strictest laws on election deepfakes.

The wife of Jane's Addiction lead singer Perry Farrell says a scuffle on stage involving her husband was caused by “tension and animosity” within the band during their reunion tour.

For centuries, eastern and western medicines have operated in separate spheres. But now a new approach to healthcare is taking root — merging the two philosophies by using the ancient practice of Chinese medicine to enhance modern treatments.

The percentage of U.S. residents born outside the country reached its highest level in more than a century in 2023.

Through tears and a smile, Alex Morgan waved to the crowd and walked off the field for the last time on Sunday.

At Major League Baseball's All-Star break, the one award race that seemed like it might be over was for National League Rookie of the Year.

U.S. authorities say arrests for illegal border crossings from Mexico during August are expected to rise slightly from July.

A San Diego police officer killed when a fleeing vehicle crashed into his patrol car had been with the department since 2019.

A San Diego police officer was killed and another was critically injured when a speeding vehicle crashed into their patrol car.

The two giant pandas sent from China to the United States earlier this year are making their public debut at the San Diego Zoo.

A cancer diagnosis is life-changing, not only for the people who are diagnosed, but also for their loved ones. Often relationships are impacted by the stress of the unknown.

The “Dexter” universe is expanding, with everyone’s favorite serial killer coming back from the dead.

“Deadpool & Wolverine” has swept through Comic-Con, with its hordes of Marvel fans, with a surprise screening and the film's stars and thousands of fans.

Juan Soto has come and gone.

Guardians rookie Angel Martinez blooped a single to center in the seventh inning to break up a no-hit bid by San Diego's Michael King.

Pittsburgh pitcher Paul Skenes was picked for the All-Star Game just eight weeks after his debut, and major league-leading Philadelphia had a big league-high seven selections.

The area is well represented in minor league baseball. Each week on Friday, News4JAX will chart how local players are doing in affiliate minor league baseball.

President Joe Biden has suspended asylum processing at the U.S. border.

Many people start no-buy challenges at the beginning of the year and commit to keep going until the end of it.

U.S. figures show that San Diego became the busiest corridor for illegal crossings in April.

Shohei Ohtani was not in the Dodgers’ starting lineup against the San Diego Padres on Sunday because of back tightness that forced him to exit a game Saturday night.

Los Angeles Dodgers star designated hitter Shohei Ohtani left after his fourth at-bat in a 5-0 win over the San Diego Padres with what manager Dave Roberts said was back tightness.

The mother of two Australian surfers killed in Mexico has delivered a moving tribute to her sons at a beach in San Diego.

San Diego acquired two-time batting champion Luis Arraez from the Miami Marlins along with nearly $7.9 million in a deal for four players that left the Padres responsible only for the major league minimum salary.

With the expanded College Football Playoff locked in through 2031, questions still remain about what the rest of the postseason will look like.

The White House says teamwork between the U.S. and Mexico to crack down on illegal migration is paying off.

San Francisco is the latest U_S_ city preparing to receive a pair of pandas from China, in a continuation of Beijing’s famed “panda diplomacy.”.

Arrests for crossing the U.S. border illegally fell slightly in March, bucking a usual spring increase amid increased immigration enforcement in Mexico.

A federal judge sharply questions the Biden administration’s position that it bears no responsibility for housing and feeding migrant children who are waiting for agents in makeshift camps.

While the women will send its best team, the men will send an under-23 team with three over-age exceptions.

Yoshinobu Yamamoto was chased after one inning of a nightmarish major league debut and the San Diego Padres outlasted the Dodgers 15-11 after Los Angeles fired Shohei Ohtani’s interpreter following allegations of illegal gambling.

A person familiar with the negotiations tells The Associated Press that two-time Cy Young Award winner Blake Snell and the San Francisco Giants have agreed to a $62 million, two-year contract.

Alex Morgan scored in the 88th minute and the San Diego Wave won the Challenge Cup with a 1-0 victory over Gotham FC Friday night in the National Women’s Soccer League.

Alyssa Naeher had three saves in the penalty shootout after a rain-soaked 2-2 draw with Canada on Wednesday night, earning the United States a spot in the CONCACAF Women’s Gold Cup final.

Tennis, pickleball, golf, running – millions of people will suffer from over-use injuries this year. The pain can literally stop you in your tracks. When physical therapy and medications don’t help, surgery is usually the only option. But now, there’s a new minimally invasive procedure that will help ease your pain and get you back out doing what you love.

Buses dropped off hundreds of migrants at a San Diego bus stop instead of at a reception center that had been serving as a staging area because it ran out of local funding sooner than expected.

Only four pandas remain in the United States.

The Marine Corps has released the names of the five Marines killed when their helicopter went down in the mountains outside San Diego during a historic storm.

Artificial intelligence is revolutionizing the healthcare landscape, particularly in cardiovascular medicine. From precise diagnosis to personalized treatment plans, medical professionals are leveraging AI technologies to help save lives.

The military says efforts are underway to recover the remains of five U.S. Marines who were killed when their helicopter went down during stormy weather in the mountains outside of San Diego.

Rescuers were battling heavy snow to reach a Marine Corps helicopter carrying five troops that went down in a mountainous area outside San Diego.

A sweeping Senate bill on border security would bring dramatic changes to places like Jacumba Hot Springs, where hundreds of migrants wiggle through a border wall with Mexico every day in boulder-strewn mountains near San Diego to surrender to border agents and seek asylum.

The first of back-to-back atmospheric rivers is drenching California.

Kevin Yu of Taiwan shot an 8-under 64 on the North Course at Torrey Pines to take a one-shot lead over Patrick Cantlay and Ryo Hisatsune in the opening round of the Farmers Insurance Open.

Nick Dunlap is the first amateur in 33 years to win on the PGA Tour.

Flash floods inundated homes and overturned cars in Southern California as torrential rain swept through a large swath of the U.S. Over a three-hour period on Monday, a whopping 3 inches of rain fell near San Diego.

Breeze Airways announced it will be adding a nonstop service from Jacksonville to San Diego, California starting May 1.

A Pacific storm that pounded coastal areas northwest of Los Angeles has pushed through San Diego to the deserts on its way into Arizona.

Juan Soto’s arrival is a sign the New York Yankees want stars to help them rebound from their worst season in three decades.

The first lesbian leader of the California Senate is thinking about trying to make history again — with a run for the governor's office.

San Diego Padres owner Peter Seidler has died.

The event is free to spectators and will also feature a festival, food and concert.

The National Women’s Soccer League on Thursday announced a new media rights deal that will feature the league’s matches on ESPN, CBS Sports, Amazon Prime Video and Scripps Sports.

Veronica Latsko scored the lone goal on Sunday as OL Reign defeated the San Diego Wave in the National Women’s Soccer League playoff semifinals.

Nelson Cruz says he is retiring at age 43 after hitting 464 home runs in 19 major league seasons.

A major influx of Chinese migration to the United States on a relatively new and perilous route through Panama's Darién Gap jungle has become increasingly popular thanks to social media.

The U.S. Customs and Border Protection has announced a new government-wide strategy that will target not only fentanyl but precursor materials used to make the synthetic opioid.

San Diego's well-oiled system of migrant shelters is being tested like never before as U.S. Customs and Border Protection releases migrants to the streets of California’s second-largest city because shelters are full.

There were just 2,459 errors entering the final weekend of the regular season, on track to finish as the fewest in a non-shortened year since 1960 when there were just 16 teams.

Padres left-hander Blake Snell took a no-hitter though seven innings before being replaced by reliever Robert Suarez in the eighth against the Colorado Rockies.

Felony convictions have been vacated for four former Navy officers in a sprawling bribery scandal due to prosecutorial misconduct.

Farmers Insurance says it will lay off 11% of its workforce — about 2,400 employees — as part of a corporate restructuring aimed at increasing its efficiency and long-term profitability.

The U.S. military has identified the Marine Corps pilot who was killed when his combat jet crashed near a San Diego base during a training flight.

San Diego Padres reliever Robert Suárez has been suspended for 10 games by Major League Baseball, the sixth pitcher penalized for using banned sticky stuff.

Spanish singer Miguel Bosé says 10 armed assailants burst into his house in Mexico City and tied him, his two children and household staff for two hours while they ransacked the premises.

Deadly floodwaters have inundated streets along the length of Mexico’s arid Baja California, where Tropical Storm Hilary came ashore Sunday.

Tropical Storm Hilary is swirling northward just off the coast of Mexico’s Baja California peninsula.

United States goalkeeper Matt Turner has joined Nottingham Forest from Arsenal for a reported 10 million pounds ($12.75 million).

U.S. authorities are sharply expanding the reach of curfews for the heads of asylum-seeking families while they wait for initial screenings after crossing the border.

Scientists actually are predicting that children born today will, on average, live to be over 120 years old. What does the future of aging have in store for us?

The new jackpot for Wednesday’s drawing would be the seventh highest in U.S. history and the third largest for Powerball.

The new jackpot for Wednesday’s drawing would be the seventh highest in U.S. history and the third largest for Powerball.

All-Star center fielder Mike Trout of the Los Angeles Angels had surgery on his fractured left wrist, two days after he was injured while fouling off a pitch.

Shohei Ohtani says he's not planning to pitch in the All-Star Game next week after leaving the Los Angeles Angels’ 8-5 loss to the San Diego Padres with a blister on the middle finger of his right hand Tuesday.

For the second straight day, a video review overturned a call at home plate and had a significant impact on a game’s outcome.

Mike Yastrzemski splashed a game-ending three-run homer into McCovey Cove in the 10th inning, and the San Francisco Giants rallied past the San Diego Padres 7-4 for their season-best eighth straight victory.

Diego Cocca was fired as coach of Mexico’s national team, four days after a 3-0 loss to the United States in a CONCACAF Nations League semifinal.

Relatives of a late Black businessman who helped popularize Juneteenth in San Diego are suing a cemetery after his remains were reported missing from the family’s burial plot.

The U.S. Border Patrol chief says a 4-year-old child is “remarkably" OK after being dropped into the United States from a high border wall from Tijuana, Mexico.

A San Diego club will join Major League Soccer in 2025, becoming the league’s 30th team.

San Diego Padres pitcher Michael Wacha took a no-hitter into the eighth inning before Michael Massey of the Kansas City Royals lined a leadoff single.

Former Buffalo Bills punter Matt Araiza was not present when an alleged gang rape of a minor occurred at an October 2021 party in San Diego nor was he visible in videos recovered after the incident, which led to a police investigation and a lawsuit by the woman who said she was attacked, according to witness testimony.

Mookie Betts hit a game-tying homer with two outs in the ninth inning and James Outman hit a two-run shot in the 10th to give the Los Angeles Dodgers a 5-2 win over the San Diego Padres.

New York's Metropolitan Transportation Authority, which for 14 years has provided real-time information on subway, train and bus service outages, delays and other important updates for its 1.3 million followers, will stop using Twitter for such alerts.

Max Scherzer shut down the San Diego Padres for five innings, rebounding from his postseason flop against them last year, and the New York Mets won 5-0 in a playoff rematch between National League heavyweights.

Pinch-hitter David Dahl and Kim Ha-seong hit consecutive home runs opening the bottom of the ninth inning, and the San Diego Padres stunned the Arizona Diamondbacks 5-4.

A beloved Golden Retriever who found her calling as a therapy dog when she learned to surf, has died in Southern California.

With spring now underway, California's 39 million residents are hopeful for sunnier days ahead.

California prosecutors have dropped domestic violence charges against Justin Roiland, who created the animated series “Rick and Morty” and provided the voices of the show’s two title characters.

Mexican officials say at least seven of eight people killed when two boats capsized in shallow but turbulent surf off the San Diego coast were Mexican migrants.

President Joe Biden and the leaders of Australia and the United Kingdom have announced that Australia will buy nuclear-powered attack submarines from the U.S. to modernize its fleet.

Authorities say at least eight people were killed when two migrant smuggling boats overturned off the coast of San Diego.