Patrick Mahomes is battling another ankle injury.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.

The Bills are already missing suspended pass rusher Von Miller.

The Buffalo Bills have grown accustomed to spending the first month of the season leaning on backups stepping up on a depleted defense.

A year after making the cut to successfully resume his football career following a near-death experience, Buffalo Bills safety Damar Hamlin reached a new plateau in his comeback in being selected a season-opening starter.

The Buffalo Bills’ salary cap-related purge of players cut deep into the team’s core.

Damar Hamlin’s objective to resume his playing career after a near-death experience in early January became complete when the Bills safety took the field as part of Buffalo’s kickoff return unit to open its game against the Miami Dolphins.

Buffalo Bills starting safety Jordan Poyer was ruled out from playing against the Miami Dolphins this weekend, potentially opening the door for Damar Hamlin to appear in his first regular-season game since going into cardiac arrest during a game in January.

DeMarcus Lawrence returned a fumble 19 yards for a touchdown on the Rams’ opening drive, and Cooper Rush remained unbeaten as the Dallas Cowboys’ fill-in starter despite passing for just 102 yards in a 22-10 victory over Los Angeles.

Deebo Samuel turned a short catch into an electric 57-yard touchdown, Talanoa Hufanga returned an interception for a score and the San Francisco 49ers beat the Los Angeles Rams 24-9.

No team in the NFL is built like the Los Angeles Rams because nobody else would dare.

Matthew Stafford passed for 202 yards and two touchdowns in his first playoff victory and the Los Angeles Rams roared out of the wild-card round with a 34-11 win over the Arizona Cardinals.

Safety Eric Weddle is coming out of retirement to rejoin the Los Angeles Rams for the playoffs.

Cooper Kupp is finishing up one of the greatest seasons by a receiver in NFL history.

Cooper Kupp caught two touchdown passes from Matthew Stafford in the second half, and the Los Angeles Rams held off the Seattle Seahawks 20-10 in a rescheduled game between two COVID-19-depleted teams.

Josh Reynolds and Gerald Everett caught touchdown passes from Jared Goff, and the Rams won a matchup of dominant defenses, beating the Bears 24-10. After his first sack, Floyd jumped up and went toward the Bears sideline, shouting and gesticulating at the team that let him go. We’re just one tight unit right now.”The Rams led 10-3 at halftime after holding the Bears to 126 yards. ... TE Tyler Higbee was inactive with a hand injury, missing his second game since 2016. Johnny Mundt had a career-high 47 yards receiving in his absence, including a career-best 34-yard catch in the second quarter.